Chronic diseases can be caused by a multitude of factors including numerous environmental exposures. To better understand how exposures to mixed contaminants in water may relate to gastric cancer rates, we exposed gastric organoids to a mixed matrix of contaminants to quantify how targeted health outcomes change with exposure scenarios. Preliminary results indicate increased H. pylori infection and cancer markers with increased arsenic concentrations. Results are important for identifying at risk communities and preventing gastric cancers. This project was funded by the University of Arizona.